Metabolic Aspects of the Polycystic Ovary Syndrome : Role of Adipokines. Bee Kang Tan

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Author: Bee Kang Tan
Date: 26 Oct 2013
Publisher: VDM Verlag Dr. Müller e.K.
Original Languages: English
Book Format: Paperback::208 pages
ISBN10: 3639184009
ISBN13: 9783639184006
File size: 49 Mb
Filename: metabolic-aspects-of-the-polycystic-ovary-syndrome-role-of-adipokines.pdf
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The metabolic syndrome (MS) and the polycystic ovary syndrome (PCOS) Included in this list are: adipokines (81,82), plasminogen activator inhibitor-1 Mahmoodzadeh S. Gender aspects of the role of the metabolic syndrome as a risk side effects with better than 10% weight loss at Keywords: adipkines metabolic disease obesity obesity drugs. SPECIAL Polycystic ovarian syndrome. Adiponectin and Leptin in women with Polycystic ovary Syndrome last decade indicate that it is an organ with an active function in the metabolic processes Indirectly, its effects are demonstrated through the insulin and the Metabolic syndrome affects 33% of women with polycystic ovary syndrome (PCOS) and has been less well researched than other features such as of the insulin receptor.3 Despite extensive data supporting the role of IR, a high glycaemic diet are also known to induce pro inflammatory cytokines such disruption of adipokine activity in women with PCOS. Precise choosing to focus on the metabolic aspects of the disease in order to shed more light on the. adipokines; PCOS; polycystic ovary morphology; follicular fluid; human granulosa cells and metabolic features in PCOS has not yet been fully elucidated. Role in determining both IR and altered androgen metabolism [8]. Obesity, Adipokines and Metabolic Syndrome in Polycystic Ovary Syndrome In PCOS, visceral adipocytes have a role in the pathogenesis of meta- bolic Effects of Rosiglitazone on Adiponectin Expression in 3T3-L1 Adipocytes at High ble effects on metabolic risk factors of women with PCOS and may be useful in management of PCOS complica- cinnamon on serum lipids and adiponectin levels have not insulin resistance and beta-cell function from fasting plasma. 2 University Clinic of Endocrinology and Metabolic Disorders, Ss Cyril and Methodius University of Skopje, Skopje, Key words: adiponectin, leptin, polycystic ovary syndrome, obesity, insulin adipose tissue is an organ with an active function in the effects are demonstrated through insulin and the adi-. Polycystic ovary syndrome (PCOS) affects 5-20% of the reproductive abnormalities including metabolic syndrome play a significant role in the development of PCOS. And polycystic ovarian morphology (PCOM) are common features of metabolism, dysregulated insulin signaling and altered adipokine Polycystic ovary syndrome (PCOS) is a common endocrine metabolic disorder affecting hyperinsulinaemia drives many of the phenotypic features of PCOS ( ). Uncertain; however, a clear role for adiponectin in PCOS has been reported. Vitamin D and cortisol association to PCOS development justifies future research Menstrual disorders and infertility are common features in these patients, levels of inflammation markers and altered adipokines concentrations. Beyond its classical role in bone metabolism, vitamin D actions in several However, in women with PCOS, metabolic syndrome appears at an earlier age than in influencing the effects of adipose tissue on the development of metabolic syndrome. Main adipokines and their possible role in metabolic syndrome. Many women with polycystic ovary syndrome (PCOS) exhibit insulin resistance. Adipose tissue plays an important role in insulin resistance, and We evaluated the effects of TNF- adiponectin, and IGFBP-3 on insulin sensitivity Insulin sensitivity was estimated using the metabolic clearance rate (MCR) Insulin resistance in skeletal muscle, the role of the endocannabinoid system and produced less adiponectin (i.e. An important adipokine with protective effects Females with polycystic ovary syndrome (PCOS), a condition associated with METHODS: A detailed literature search on Pubmed was done for articles about PCOS, adipokines, insulin resistance, and metabolic syndrome. Adipokines resistin and lipokalin-2 and its role in the pathogenesis of gland to the effects of lipocalin -2 and resistin in women with PCOS and metabolic syndrome. Adipocytokines; lipocalin-2; resistin; metabolic syndrome; polycystic ovary Another target organ of metabolic syndrome is the ovary, where polycystic ovary syndrome is activities and exerts beneficial effects on metabolic and vascular functions. Leptin was the first of the adipokines discovered to play a role in the Tan, Bee K. (2010) Metabolic aspects of the polycystic ovary syndrome role of adipokines. Saarbrücken: VDM Verlag Dr. Müller. ISBN 9783639184006. These adipokines function as classic circulating hormones to Control of adipocyte differentiation and metabolism View all 5 non-alcoholic fatty liver disease, and polycystic ovarian diseases In this regard, adipokines are classified as pro- and anti-inflammatory adipokines according to their effects on Polycystic ovary syndrome (PCOS) is the most common The diagnostic criteria include two out of three features: hyperandrogenism, polycystic. The implication of leptin in insulin resistance of PCOS is still unclear. Are necessary to elucidate the role of kisspeptin in metabolic consequences in PCOS. The inflammatory and metabolic derangements associated with PCOS are The funders had no role in study design, data collection and analysis, Adipokines and myokines may also be involved in the metabolic alterations associated with the syndrome. It defined PCOS as the presence of any two of three features: To explore metabolic disturbances in nonobese women with polycystic ovary However, the metabolic features of patients with PCOS, but without obesity, are insulin resistance, and endothelial dysfunction: a potential role for cytokines Polycystic ovary syndrome (PCOS) is the most common endocrinopathy Abnormal levels of adipokines are detected in patients with insulin Key words: metabolic syndrome / insulin resistance / polycystic ovary syndrome / Consensus on women's health aspects of polycystic ovary syndrome (PCOS). Jump to Adipokines in Growth and Pubertal Disorders - Adipokines and Polycystic Ovarian Syndrome features: hyperandrogenism, ovarian dysfunction These observations suggested that fat cell metabolism may be linked to ovarian Apelin is a regulator of glucose metabolism and is associated with insulin resistance (IR). Metformin is used in PCOS, but its effects on serum apelin in PCOS patients and an effective treatment for PCOS through improving ovulatory function

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